Roles of Toll-Like Receptors in C-C Chemokine Production by Renal Tubular Epithelial Cells

Epithelial Cells Chemokine Production by Renal Tubular Roles of Toll-Like Receptors in C-C

Toll-like receptor 4 engagement contributes to expression of NKG2D ligands by renal tubular epithelial cells.

BACKGROUND Engagement of Toll-like receptor (TLR) 4 on intrinsic kidney cells is critical for the full development of renal ischaemia-reperfusion injury (IRI). Effects of TLR signalling in renal parenchymal cells include the production of cytokines, chemokines and other soluble mediators which contribute to local inflammation and leucocyte accumulation. Whether engagement of TLR4 on kidney cell...

Tangeretin protects renal tubular epithelial cells against experimental cisplatin toxicity

Objective(s): Cisplatin is an effective antineoplastic agent; its clinical utility, however, is limited by a few salient toxic side effects like nephrotoxicity. This study aimed to determine the potential protective effects of tangeretin, a citrus-derived flavonoid, against renal tubular cell injury in cisplatin-induced renal toxicity of rats.Materials and Methods: Tangeretin was injected intra...

AGE-LDL Activates Toll Like Receptor 4 Pathway and Promotes Inflammatory Cytokines Production in Renal Tubular Epithelial Cells

BACKGROUND/AIMS Accumulation of advanced glycation end-products, the well-recognized pro-inflammatory molecules, has been detected in renal tissues including tubules. The aim of the present study was to investigate the role of advanced glycation end-products modified low density lipoprotein (AGE-LDL) in inflammatory cytokines production in human proximal tubular epithelial cells and the underly...

O-34: Cell Membrane Toll like Receptors Expression in Follicular Cells of Women with Endometriosis

Background: Endometriosis is the growth of endometrial cells outside the uterine cavity. It has been suggested that immune system plays important roles in both initiation and progression of the disease. Several studies have been shown that women with endometriosis diverge in their expression of different genes including heat-shock proteins, fibronectin, and neutrophil elastase, which might be i...